Analgesic effect of chronic oral administration of aerial Part of Marrubium Vulgare in diabetic rats

ABSTRACT

Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare [MV], this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response [standard formalin test] in diabetic rats. Forty-eight rats were randomly divided into control, MV-treated control diabetic sodium salicylate [SS]-treated diabetic, sodium salicylate [SS]-treated control and MV-treated diabetic groups. For induction of diabetes, streptozotocin was used at a single dose. The treatment groups received oral administration of MV-mixed pelleted food [6.25%] for two months. In this study, administration of sodium salicylate to control and diabetic groups caused a significant reduction in pain score in the second phase of formalin test [p<0.05 and p<0.01, respectively]. On the other hand, administration of marrubium vulgare for two months to control and diabetic groups caused a significant reduction in pain score at both phases of the formalin test [21.3% [p<0.05] and 18.4% reductions [p<0.05]] in control and diabetic groups [17.6% [p<0.05] and 17.9% reductions [p< 0.05]] as compared to untreated control and diabetic groups. The results indicate that administration of marrubium vulgare could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy