Comparison of Lidocaine and magnesium sulfate on hemodynamic changes in response to endotracheal intubation

ABSTRACT

Laryngoscopy and endotracheal intubation may produce adverse hemodynamic effects such as hypertension and tachycardia. To attenuate these stimulating responses, various methods and drugs were recommended. The objective of this study was to compare the effect of lidocaine and magnesium sulfate on hemodynamic changes in response to endotracheal intubation. In this study, 100 patients [ASA class I-II] were selected and divided randomly into two groups [50 patients in each group]. Premedication and induction drugs were the same in both groups according to weight. In case group, magnesium sulfates 40mg/kg [50%] and in control group, lidocaine lmg/kg [1%] was used before induction of anesthesia. In both groups, BP and HR checked in all patients and recorded before and after premedication after induction and in the 1st, 3rd, 5th minutes after endotracheal intubation. Data were analyzed by SPSS. T-test was used to compare the mean heart rate and systolic and diastolic blood pressure in different time and p<0.05 was considered significant. Two groups were equal in ASA class, frequency distribution of gender and age, HR, systolic and diastolic BP before and after premedication. But decrease in BP and HR after inducation of anesthesia in control group was more than study group [p<0.05]. There were no significant differences between two groups in mean BP and HR in the 1st, 3rd, 5th minutes after endotracheal intubation. Magnesium sulfate and lidocaine have the same effect on attenuating cardiovascular responses to endotracheal intubation