Biochemical and molecular studies on the hepatoprotective effect of ginger
Journal of Drug Research of Egypt. 2006; 27 (1-2): 14-22
in English
| IMEMR
| ID: emr-77744
ABSTRACT
The hepatoprotective effect of acetone soluble fraction [ASF] of petroleum ether extract of ginger was evaluated in vivo by using CC1[4] model, which induced hepatotoxicity. The results revealed that the activities of ALP, AST, ALT and TBARS were increased after adminsitraiton of CC1[4]. This effect of CC1[4] This effect of CCL[4] was attenuated by acetone soluble fraction of ginger by two doses. Also, lysosomal enzymes were markedly increased after administration of CC1[4], but this effect was ameliorated by ASF of ginger nearly to the control group. These results demonstrate that acetone soluble fraction of ginger plant exerted a hepatoprotective activity in vitro and in vivo and may be useful in the treatment of hepatotoxicity and liver diseases
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Carbon Tetrachloride
/
Protective Agents
/
Models, Animal
/
Liver
/
Liver Function Tests
Limits:
Animals
Language:
English
Journal:
J. Drug Res. Egypt
Year:
2006
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