effect of different garlic extracts against oxidative stress induced in streptozotocin diabetic rats

ABSTRACT

The present study is a trial for minimizing the oxidative stress that may be one of the risk factors responsible for diabetic complications. For this purpose, different forms of garlic extracts were investigated using diabetic rats. Hyperglycemia was induced in male albino rats by IP injection of streptozotocin [STZ] in a total dose of 50 mg/Kg b.wt. STZ-diabetic rats were treated orally with garlic oil [10 mg/Kg b.wt.], fresh garlic extract [10 ml/Kg b.wt.] and aged garlic exract [800 microl/Kg b.wt.] daily for three weeks. The data revealed that, STZ injection induced a significant increase in plasma glucose level, plasma and liver malondialdehyde [MDA] concentrations. The significant increase in the activities of antioxidant enzyme [total superoxide dismutase [SOD] glutathione peroxidase [GSHPx] and catalase] in liver homogenate was associated with a significant reduction in blood-reduced glutathione [GSH]. The treatment of diabetic rats by different forms of garlic revealed that, aged garlic extract exhibited a more pronounced hypoglycemic and antioxidant effect followed by fresh garlic extract then garlic oil