[Effect of Aegle marmelos fruit juice concentrate on serum glucose and lipid level and ALT/AST activities in diabetic rats]

ABSTRACT

This study was carried out to investigate the effect of bael [Aegle marmelos] on glucose, cholesterol, triglyceride, creatinine levels and the activity of ALT and AST in the serum of diabetic rats. 45 Adult male Sprague Dawley rats were selected. The rats were divided into three groups. The first group was considered as negative control [non-diabetic rats] and diabetes mellitus was induced in the remained rats by I.V. injection of alloxan [50 mg/kg BW]. Following induction of diabetes mellitus 15 diabetic rats were considered as positive control and 15 ones as treatment group. Treatment group was fed with homogenous mixture of ordinary rat food and Bael concentrate [2gr/kg food] for three weeks and the remaining groups were fed with ordinary rat food. Following induction of diabetes mellitus, concentration of serum glucose, cholesterol, triglyceride and the activity of ALT increased significantly [P<0.01], but AST activity and creatinine concentration not varied. Food and water intake was increased and body weight of rats was decreased [p<0.01]. Consumption of bael concentrate caused a significant decrease in serum glucose, cholesterol, triglyceride and the activity of ALT [P<0.01], and also food and water intake was decreased [p<0.01]. The results of this study show that Aegle marmelos concentrate exhibit hypoglycemic and hypolipidaemic effects in diabetic rats