[Identification of helicobater pylori in sinonasal mucosa of patients with chronic sinusitis]

ABSTRACT

Helicobacter pylori is a microaerophilic, gram negative, spiral organism. Which plays arole in the development of gastritis, duodenal gastric ulcer, and gastric cancer. Helicobacter pylori normally inhabits the human gastric mucus layer. Previous studies have shown by colonization Helicobacter in dental plaque, saliva, tonsils, adenoids and oral cavity lesions. Sinusitis is the most common hygienic problem in the world and a yearly large part of the budget is spent in the diagnosis and treatment of this problem. There are various theories for possible modes of Helicobacter pylori transmission. Although, there is a relation between colonization of Helicobacter pylori in upper gastrointestinal tract and gastro esophageal reflux. So an investigation to identify the presence of helicobacter pylori in the mucosa of the sinonasal of patients with chronic sinusitis will be needed. In the present study we used the polymerase chain reaction [PCR] and urease test [CLO] to investigate the Helicobacter pylori status of paranasal sinus mucosa specimens, obtained from patients with chronic sinusitis. The present study is designed as case-control. The study was performed on 44 patients who were admitted in the ENT clinic between April 2004 and July 2005.22 patients suffered from chronic sinusitis. All medication in this group had failed. So, these patients were selected for endoscopic surgery of sinus. This group was named the case group [22 patients]. Those who had septal deviation without sinusitis, was named the control group. We obtained two endoscopic biopsy specimens from each side of nasal mucosa of patients. These specimens were studied by the CLO test and PCR for helicobacter pylori. Helicobacter pylori was not detected in the mucosa of sinonasal of patients. According to the present ideas, the presence of helicobacter pylori in the mucosa of sinonasal of patients with chronic sinusitis is of low probability