Comparative haematological and hepatorenal toxicity of IGR, lufenuron and profenofos insecticide on albino rats

ABSTRACT

The present investigation was conducted to compare the toxicity of the IGR, lufenuron and the organophosphorus insecticide, profenofos on blood content, liver and kidney functions of male albino rats. The tested compounds were orally administered to rats at 1/20 and 1/10 of their median lethal doses [LD50s] for two months [day after another], then toxicants were withdrawn for 30 days to allow recovery of toxic effects. Data indicated that 1/10 LD50 of both compounds caused significant changes on blood contents and biochemical parameters of treated rats without return to normal levels at the end of recovery period, while, the smallest dose revealed negligible changes on some tested parameters with resumed normal values. The adverse effects reached its peak at 45 and 60 days of treatment [high dose treated rats] followed by decrease during recovery intervals without returned to normal, but at 1/10 LD50, lufenuron caused sever damage on kidney; urea and creatinine showed high levels at the end of recovery periods [92.0 and 220.0% above normal level, respectively]. Data indicated that, 1/10 LD50 of lufenuron treated rats exhibited changes in leucocytes, platelets counts, transaminases activities, creatinine and urea concentrations more than the organophosphorus insecticide. On the contrary, the same dose of profenofos mostly affected on erythrocytes counts, haemoglobin levels and alkaline phosphatase [ALP] activity. The obtained data would suggest that the two tested compounds at high dose have an inhibitory action on haemopiesis. In addition, both compounds proved to have comparable toxicity towards animals