Hepatic and renal biochemical responses to the toxicological interaction between acetylsalicylic acid and diazinon in albino rats

ABSTRACT

The present investigation is aiming at studying the effect of administrating sublethal dose of the insecticide "Diazinon" with and without acetylsalicylic acid [Aspirin, ASA]. Sixty male albino rats were given orally 1/30 LD50 of the insecticide "Diazinon", with and without the high therapeutic dose of acetylsalicylic acid at a dose of [13.5mg/ kg b.w. daily] for 3 weeks. Biochemical indices of liver and kidney functions, namely serum proteins, alanine amino transferase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, cholesterol, triglyceride [TG], urea and creatinine levels were determined at the end of the experiment. The present results showed significant changes in serum ALT, AST, ALP, Biliribin, Triglyceride levels. The changes in enzyme levels indicate the toxicity of the insecticide "Diazinon" alone or in combination with the high therapeutic dose of the anti inflammatory drug "acetyl salicylic acid". The treatments did not affect the level of cholesterol or renal excretory function