Cytokines and immunoglobulin-E in certain parasitic diseases

ABSTRACT

Ninety Egyptian patients were classified into 7 groups, 6 with different parasitic infection and 10 normal controls. Forty patients with different schistosomiasis stages [1, 2 and 3] with compensated but the last one [stage 4] of decompansated schistosomiasis. Gs3 and 4 of mixed infections with schistosomiasis and HCV and HBV respectively. The last 3 patients groups were infected with toxoplasmosis, filariasis and hymenolepiasis nana. IL2, IL4 and IgE levels were measured. The results showed significant increase in IL2 [P<0.05], [P<0.01], P<0.01] and [P<0.001] among stages [1, 2, 3 and 4] versus control respectively. In chronic schistosomiasis with HCV and HBV, significance was P= <0.001 and P<0.05 respectively, among toxoplasmosis, filariasis and hymenolepiasis patients, it was P= <0.001, 0.05 and 0.01 respectively. The IL 4 level showed highly significant increase [P< 0.001] among stage 1, 2, Gs 2, 3 and 6. There was significant increase [P<0.01] with stage 3 in Gs 4 and 5 but, without significance [P>0.05] increased in decompensate schistosomiasis patients. IgE level and test of significance versus controls were given and results were discussed