Your browser doesn't support javascript.
loading
Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors
Journal of the Egyptian Society of Parasitology. 2006; 36 (3): 889-910
in English | IMEMR | ID: emr-78338
ABSTRACT
Apolymerase chain reaction [PCR], based on insertion sequence IS6110,was developed to detect mycobacterium tuberculosis complex organisms in the blood samples of 56 tuberculosis patients and 34 healthy controls.the erly secreted antigenic target 6-KDa[ESAT-6] are used to stimulate T lymphocyte subsets from tuberculosis infected patients and the correltion of these immune responses to the genetic factoes[HLATYPE] which determined the host immune response is evaluated.ESAT-6 derived peptidesP1[1.05 +/- 0.084],P2[1.08 +/- 0.094],P3[1.02 +/- 0.086],P5[0.98 +/- 0.117] and P7[1.26 +/- 0.152] were significantly higer in the infected group than in non-infected one. Besides, 33ptients and 12 controls were tested for HL-DRB HLA DQB and HLA-DPB Only type HLA-DEB 15was significan tly associated with tuberculosis infection using the Chi-square test[X[2]=0.04311]. By using the relative risk some HL types were relatively more susceptible to be associated with tuberculosis infection. HLA-DR typing of patients showed that they covered a large spectrum of HLA-DR molecules encoded by HLA-DEB1,-DRB3,-DRB4,and DRB5genes.however,HLA-DQ typing showed that they HLA-DQB1 molecules, HLA-DP typing of patients showed that covered a large spectrum of HLA-DP molecules encoded by HLA-DPB1.
Subject(s)
Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Polymerase Chain Reaction / HLA Antigens Type of study: Controlled clinical trial Limits: Female / Humans / Male Language: English Journal: J. Egypt. Soc. Parasitol. Year: 2006

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Polymerase Chain Reaction / HLA Antigens Type of study: Controlled clinical trial Limits: Female / Humans / Male Language: English Journal: J. Egypt. Soc. Parasitol. Year: 2006