Induction characteristics of two different concentrations of propofol in children undergoing eye surgeries

ABSTRACT

To compare the induction characteristics of two different concentrations of propofol [i.e. 1% and 2%] in children undergoing eye surgeries. This cross-sectional comparative study was conducted at LV Prasad Eye Institute Hyderabad India. Hundred consecutlve patients of American soclety of Anaesthesiologist [ASA] status I and II coming for elective eye surgeries were enrolled in the study. Patients were divided into two groups of 50 each. Group A were given propofol 1% while patients in Group B were given propofol 2% for induction of anaesthesia and were maintained with 1% isoflurane and 60% nitrous oxide in oxygen. Induction characteristics were assessed and compared in two groups. Student's t test and chi- square test were applied. Loss of consciousness was more rapid with propofol 2% compared with propofol 1% [40s Vs 48s; P = 0.02]. Pain on injection occurred in 5 patients [10%] and 10 patients [20%], P = 0.09 after propofol 1% and 2% respectively. Spontaneous movements during induction occurred in 8 patients [16%] and 12 patients [24%, P=0.18]. Satisfactory intubation was done in 40 patients [80%] and 45 patients [90%, P=0.19], while spasm just after intubation was noticed in 1 patient [2%] and 3 patients [6%] receiving propofol 1% and 2% respectively. Hemodynamic changes were not different in the two groups. Propofol 1% and propofol 2% are equally effective and safe for induction of anaesthesia in children undergoing eye surgeries