Effect of D-penicillamine in prevention of post operative pelvic adhesion formation in rat

ABSTRACT

Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications. Our aim was to investigate the effects of dpenicillamine in preventing adhesion formation in rat uterine horn. This experimental trial was conducted on 30 rats. The rats were randomly assigned to two groups of 15. Measurable serosal injury was created using a standard technique. The rats in one of the two groups were given 17 mg/kg of d-penicillamine. All of the animals were operated on 4 weeks after surgery and adhesions were assessed and scored by an examiner who was blind to the test. Frequency of severe adhesions in control and case groups were 76 and zero percent, respectively. Total scores of adhesions were found to be significantly reduced in the d-penicillamine treatment group when compared with control group [P = 0]. This study showed that penicillamine can decrease the chance of post-operative intra-peritoneal adhesion formation