[ effects of cimetidine on motor activity: an evaluation the role of opioid receptors]
KOOMESH-Journal of Semnan University of Medical Sciences. 2006; 7 (3-4): 119-123
in Persian
| IMEMR
| ID: emr-78852
ABSTRACT
Effects of cimetidine [CIM] on locomotor is controversial. This study was designed to evaluate the effects of CIM on motor activity and possible roles of opioid receptors in CIM-induced decrement in locomotor activity in mice. Thirty-six male mice [25-30gr] were divided into six groups in this study. Locomotor activity was evaluated using an automated activity monitor system. CIM [50 mg/kg, i.p.] was injected 25 min before testing in presence or absence naloxone [2 mg/kg, sc]. Morphine [5 mg/kg, i.p] was injected 25 min before testing in the presence or absence CIM. Decreased motor activity significantly. Pretreatment of or morphine did not change CIM - induced response significantly. The results showed that CIM significantly decreased motor activity in mice [P=0.000]. Pretreatment of nalxone did not change CIM-induced response significantly. Morphine alone did not change motor activity. Pretreatment of CIM did not change morphine-induced response. Data indicated that cimetidine can reduce motor activity independence from interaction with opioid receptors
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Receptors, Opioid
/
Mice
/
Morphine
/
Motor Activity
/
Naloxone
Limits:
Animals
Language:
Persian
Journal:
KOOMESH-J. Semnan Univ. Med. Sci.
Year:
2006
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