Breast carcinoma in Karachi. Clinical and pathological features

ABSTRACT

To evaluate the clinical presentation and morphological features of carcinoma Breast. A retrospective analysis of 50 patients that presented with Ca Breast over a period of three years in the surgical department of Lyari General Hospital and Civil Hospital Karachi. Most of the patients were in the 5th and 6th decade of life. The mean age at diagnosis was 48 years. The most common presentation was lump in the breast, out of which 12 were in left breast and 38 in the right breast. Location of lump indescending order; 18 in upper outer quadrant, 8 in outer lower quadrant, 5 in areolar reglon 3 in inner upper quadrant, 4 in inner lower quadrant, 10 patients presented with concomitant axillary lymphadenopathy, 2 with skin infiltration and distant metastatis. FNAC and Mammography correlated with H/P in 93% of cases. The most common tumor was infiltrating ductal carcinoma 81%. Tumor size was > 2 cm in 75% of cases. The number of cases with> 3 lymph node metastasis was significantly higher 70% in tumors of >2cm size. In Pakistani females breast carcinoma occurs at a younger age group. Due to unawareness, they are of large size at the time of presentation and show more frequent lymph node metastasis. Infiltrating ductal Ca is the most common type of tumor with predominance of high grade lesion