role of insulin and insulin like growth factor I [IGF-1] in Egyptian Neonates

ABSTRACT

Many growth factors have been shown to be included during fetal life. Insulin and insulin-like Growth factor-I [IGF-I] are important factors, that have major influence on fetal weighl gain and post-natal growth. In this study, we detennined the levels of cord blood insulin and insulin-like growth factor-I, in 40 healthy full term neonates, with its effect on their anthropometric measurements [head circumference, length, body weight] and gestational age. The studied neonates were delivered in Bab EI-Sharia Hospital, AI-Azhar university either by NVD [n=22] or by C.S [n= 18]. They were 24 males and 16 females. They delivered to healthy mothers [without D.M or any medical problems]. The neonates were classified according to their birth weight, maturity, and appropriance for gestational age into 15 large for gestational age [LGA], 15 small for gestational age [SGA] and 10 appropriate for gestational age [AGA] as control group. Data concerning all neonates were recorded including Mode of delivery and APGAR score. Meticulous clinical examinations to all body systems to exclude any abnormality if present Birth measurements were taken and recorded [birth weight, head circumference length and ponderal index] nsulin was measured by immunoradiometric assay and IGF-1 by radioimmuno-assay [R1A] techniques. Also, cord blood glucose was measured in all studied cases and controls. There were highly significant differences between LGA, SGA groups and AGA control group as regard birth weight, length, H, C and gestational age [p<0.01]. Also, there was significant increase in cord bl. IGF-I in LGA group as compared to AGA group [p<0.01], but no significant difference between cord bl. glucose, and cord. bl. insulin in either LGA group or SGA group compared to AGA group [p>0.05]. There were positive correlations between IGF-I and body weight, H.C and length. p<0.001 There was a positive correlation between cord bl. IGF.I and cord. bl. insulin [p<0.01]. But a negative correlation was found between cord bl. IGF-I and cord. bl. glucose [r=-0.416] [p<0.01]. There were no significant difference between LGA, SGA and control group [AGA] as regard APGAR .score, cord bl. glucose or cord bl. insulin [p>0.05]. As. regard gender discrimenation and mode of delivery, there were no correlations or significant difference in either cord blood IGF-I nor cord bl. insulin