Effect of long acting beta 2 agonists [LABA] on vascular remodeling in asthma

ABSTRACT

Research work studying the effect of anti-asthma drugs on indices of airway remodeling especially those concerned with the increased subepithelial airway vasculrity in asthma-emetics are still few. We studied the presence of increased vascularity and the effect of LABA on vascular remodeling on 33 asthmatics who were on inhaled steroids, however, only data of 29 patients at the end of the study period [6weeks] were available for statistical studies. We confirmed by patho- logical study of bronchoscopic biopsy that there was increased vasculrity of the airways in asthmatics, even in mild cases, and that this vascularity was higher the asthma. Moreover, there was a decrease in the number of vessels/mm2 of the lamina propria at the end of the study period in all of our patients whatever the severity of their asthma and this decrease was accompanied by functional improvement, however, more pronounced the less severe the asthma