effect of low dose magnesium sulphate combined with esmolol on hemodynamic responses and recovery profile

ABSTRACT

To study the effects of low dose Magnesium sulphate combined with Esmolol on hemodynamic responses and recovery profile. During laparoscopic surgery transient acute hemodynamic responses typically occur at laryngoscopy and tracheal intubation, during insertion of the veress needle and trocars and during creation of pneumoperitoneum. MgSO[4] has been shown to inhibit catecholamine release during tracheal intubation. Patients given peri-operative MgSO[4] infusion have lower intra-and post-operative analgesic requirements. Esmolol is an ultra-short acting beta-Blocker reduces the anesthetic requirements and blunts the sympathetically mediated cardiovascular changes during surgery. 60 female patients were scheduled for diagnostic laparoscopy for gynecological causes of infertility were randomly assigned into two groups. Group I to receive low dose MgSO[4] + esmolol and Group II to receive saline. In both groups, the anesthesia was induced with fentanyl, thio-pental and atracurium, maintained with sevoflurane in O[2]. Mean HR, SBP and DBP were monitored. Recovery times and postoperative analgesic requirements were also recorded. Results showed that such co-administration can attenuate the hemodynamic responses to intubation and surgical stimulation without any side effects. Low dose MgSO[4] and esmolol can be used as an adjuvant to anesthesia for providing hemodynamic stability, shortened recovery time and decrease postoperative analgesic requirements