Role of lipid peroxidation and protein glycation in non diabetic pediatric nephrotic syndrome

ABSTRACT

In recent years, it has been proposed that nephrotic syndrome is a consequence of oxidative damage. Oxygen free radicals [OFRs] can bring about severe metabolic dysfunctions, including peroxidation of membrane lipids. Lipid peroxidation has also been reported to promote the process of protein glycation. This study was performed to evaluate the role of lipid peroxidation presented by serum Malondialdahydefructos [MDA] on protein glycation presented by level of fructosamine and the role of hypercholesterolemia in pathogenesis of nephrotic syndrome. Fifteen children with nephrotic syndrome during relapse and 12 age and sex matched healthy controls were enrolled for this study. Serum MDA, fructosamine, fasting glucose and serum cholesterol were analyzed in both groups. Serum MDA and fructosamine levels were found to be increased in nephrotic syndrome patients when compared with controls. Correlation analysis showed a significant positive correlation between fructosamine and MDA, as well as between serum cholesterol and MDA. Also a positive correlation was detected between both MDA and cholesterol with proteinuria in nephrotic syndrome patients. Present data point to a possible involvement of MDA in the glycation of proteins in non-diabetic nephrotic syndrome patients, and provide support for the potential use of an antioxidant therapy in these patients