Emerging drug - resistance and guidelines for treatment of malaria
Medicine Today. 2006; 4 (3): 81-87
in English
| IMEMR
| ID: emr-79604
ABSTRACT
The increasing prevalence of multi-resistant Plasmodium falciparum malaria worldwide is a serious public health threat to the global control of malaria, especially in poor countries like Pakistan. In many countries choloroquine-resistance is a huge problem, accounting for more than 90% of malaria cases. In Pakistan, resistance to choloroquine is on the rise and reported in up to 16-62% of Plasmodium falciparum. Four to 25% of Plasmodium falciparum is also reported to be resistant to sulfadoxine-pyrimethamine and several cases of delayed parasite clearance have been observed in patients with Plasmodium falciparum malaria treated with quinine. In this article we have introduced the concept of Artemisinin-based Combination Therapy [ACT] and emphasize the use of empiric combination therapy for all patients with Plasmodium falciparum malaria to prevent development of drug resistance and to obtain additive and synergistic killing of narasite
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phenanthrenes
/
Plasmodium falciparum
/
Pyrimethamine
/
Quinidine
/
Quinine
/
Sulfadoxine
/
Drug Resistance
/
Mefloquine
/
Malaria, Falciparum
/
Practice Guidelines as Topic
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Med. Today
Year:
2006
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