Intubating conditions and injection pain cisatracurium or rocuronium versus rocuronium cisatracurium combination

ABSTRACT

The present report evaluates the incidence of pain on intravenous injection and the condition oftracheal intubation at one minute following the administration of cisatracurium or rocuronium versus rocuronium-cisatracurium combination. We studied 60 patients, ASA 1, aged 18-60 years, undergoing elective surgical procedures. The patients were randomly assigned to 3 groups who received intravenously either 0.15 mg/kg cisatracurium [2ED[95]], 0,6 mg rocuronium [2ED[95]] or a combination of 0.075 mg/kg cisatracurium [ED[95]], plus 0.3 mg rocuronium [1ED[95]]. In the awake patients, the pain on injection of muscle relaxant was assessed on a four point scale [none, mild, moderate, severe]. Administration of the relaxant was followed by 1-2 mg/kg of lidocaine and 2 mg/kg propofol. Oro-tracheal intubation was performed 60 seconds following the administration of the relaxant. The intubating conditions were assessed and rated as excellent, good, fair or poor. The administration of 2ED[95] cisatracurium resulted in poor intubating conditions at 60s, without pain on injection. In contrast, the administration of 2ED[95] rocuronium resulted in excellent or good intubating conditions at 60s associated with high incidence of pain on injection in most of the patients. However, the combination of 1ED[95] cisatracurium with 1ED[95] rocuronium provided similar intubating conditions to the 2ED[95] rocuronium alone, associated with a significantly less pain on injection