Cefpodoxime versus trimethorim - sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in girls

ABSTRACT

Eighty two girls with uncomplicated acute lower urinary tract infection were included in a single Center r and omized study comparing Cefpodoxime suspension [5mg/kg] with trimethoprim - sulfamethoxzole [6mg/kg TMP 30/mg SMX] for 3 days. A total of 15 girls in both arms were excluded from the study for various reasons. At 4 to 7 days after the discontinuation of therapy 33 of 34 [98.4%] Cefpodoxime recipients, and 22 of 33 [66] trimethoprime-sulfamethoxzole patients, were clinically cured and demonstrated bacteriological eradication, respectively. At 28 days after treatment, 25 of 29 [87.3] and 23 of 26 [86%] cefpodoxime recipients as well as 15 of 28 [53.5] and 14 of 27 [52%] trimethoprime-sulfamethoxzole recipients, were clinically cured and demonstrated bacteriological eradication. respectively. With the expectation of two patients, in trimethoprim - sulfamethoxzole group, who discontinued therapy because of gastro intestinal pain, both antimicrobials were well tolerated. In conclusion, cefpodoxmi treatment for 3 days was more effective than trimethoprime - sulfamethoxzole for 3 days for the treatment of uncomplicated acute cystitis in girls