Evaluation of post challenge Glucose Estimation For Diagnosis of Gestational Diabetes Mellitus [W.H.O. - Criteria 1999]

ABSTRACT

To compare sensitivity, specificity and Positive Predictive Value [PPV] and Negative Predictive Value [NPV] of 75g Oral Glucose Tolerance Test [OGTT] i.e. WHO criteria 1999 with 100g OGTT of National Diabetes Data Group [NDDG criteria]. Study Design: Comparative cross sectional. Material and Methods:The study was conducted at Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology [AFIP], Rawalpindi. Duration of study 1st January 2004 to 31st August 2004. Sample size Approx one hundred pregnant ladies between 24 to 28 gestational weeks. Sampling technique Non-probability convenience. Data collection procedure Patients consent for participation in the study was taken with explanation of test procedure. Patient's characteristics such as age, obesity, family history of diabetes, pregnancy induced hypertension, previous bad obstetric history [of still birth, macrosomia, recurrence abortion] was recorded on a predesigned proforma. Patients were first called for 75g OGTT and then after a gap of 1-2 days for OGTT 100g. Both tests were performed according to standard protocols. OGTT 75g was found to have 87.5% sensitivity, 97.8% specificity, and 77.7% positive predictive value and 98.8% negative predictive value, when compared with 100g OGTT