Effect of hexane extract of boswellia serrata oleo-gum resin on chemically induced liver damage

ABSTRACT

The hexane extract of oleo-gum-resin of Boswellia serrata [BSHE] was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The BSHE was given in two different doses [87.5 mg/kg p.o. and 175mg/kg p.o.]. Silymarin, a known hepatoprotective agent was used as standard. The lower dose of BSHE [87.5mg/kg p.o.] significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of BSHE was supported by changes in histopathology. It was concluded that hexane extract of oleo-gum-resin of Boswellia serrata plant in lower doses possess hepatoprotective activity