Revue Marocaine de Medecine et Sante. 1986; 8 (1): 27-31
in French
| IMEMR
| ID: emr-8044
ABSTRACT
The cardiovascular effects of oxodipine, a new calcium antagonist compound have been investigated in 30 anesthetized dog [pentobarbital 25 mg kg[-1] I.V.]. Heart rate and arterial pressure were continuously monitored. Oxodipine injected at 10, 15 and 75 mcg kg[-1] produces a significant hypotensive without change in heart rate. The L D 100 of oxodipine was determined by perfusion at rate of 75 mcg kg[-1], that of nifedipine at rate of 40 mcg kg[-1] min[-1]. Oxodipine appears as active as infedipine. The two compound present a structural analogy and the similar pharmacological profile of antihypertensive type, by predominant arterial action
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Blood Pressure
/
Calcium Channel Blockers
/
Nifedipine
/
Cardiovascular System
/
Dogs
/
Heart Rate
/
Anesthesia
Limits:
Animals
Language:
French
Journal:
Rev. Marocaine Med. Sante
Year:
1986
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