Effect of ozone on some blood coagulation patterns in male albino rats

ABSTRACT

In this study forty adult male albino rats were used to investigate the effect of ozone on some coagulation patterns. Rats were divided into four equal groups, i.e. control group, immobilization stress group, immobilization plus small dose ozone group and immobilization plus large dose ozone group. In each group prothrombin time [PT], partial prothrombin time [PPT], platelet count, malonyldialdehyde, and catalase enzymes were measured. The results showed that immobilization stress led to significant increase in prothrombin time, partial prothrombin time and malonyldialdehyde with significant decrease in platelet count and catalase enzyme as compared to control group. Ozone in small dose led to significant decrease in prothrombin time, partial prothrombin time and malonyldialdehyde with significant increase in platelet count and catalase enzyme as compared to immobilization stress group. Ozone in large dose led to significant decrease in prothrombin time, partial prothrombin time and malonyldialdehyde with significant increase in platelet count and catalase enzyme as compared to immobilization stress group. The results of this study showed that immobilization stress had hypocoagulability effects and that ozone in large and small doses had improved these immobilization-induced hypocoagulability changes