Thrombomodulin as a marker of endothelial damage and severity in pre-eclampsia/eclampsia syndrome

ABSTRACT

Preeciampsia is an idiopathic multisystem disorder specific to human pregnancy characterized by gestational hypertension and proteinuria. It complicates many pregnancies and is the third common cause of maternal mortality. It is also associated with a high perinatal mortality and morbidity. The aim of the present work was to study Thrombomodulin [TM] as a marker of endothelial damage in pre-eclampsia/ eclampsia syndrome Eighty pregnant females in the second half of pregnancy were enrolled in the study divided into control group [I], mild preeclampsia [IIa], severe preeclampsia [IIb], and eclampsia [IIc]. Thrombomodulin was measured by ELISA technique at presentation and 3 days post partum. The results showed that the level of TM is higher in patients with eclampsia and preeclampsia compared to the control group, furthermore, the level decreased with delivery and subsidence of the condition. In conclusion TM can be used as a marker for monitoring preeclampsia/ eclampsia syndrome