Liver functions in febrile children treated with some antipyretic drugs

ABSTRACT

This work is carried out on 45 febrile children from both sexes, their ages ranged from 3 - 12 years, with upper respiratory infection, they were divided into three equal groups. The 1[st] group treated with aspirin, the 2[nd] with acetaminophen, the 3[rd] with dipyrone in therapeutic doses. None of the cases had clinical features of hepatitis. Every child in the study was subjected to a thorough history taking, physical examination and measurement of serum transaminases [SGPT, SGOT], serum glutamyl transpeptidase [GGT] and prothrombin activity [PTA] were done before and after administration of each drug. The results revealed significant increase in SGPT, SGOT, GGT after administration of each drug accompanied with insignificant change in [PTA] in all cases The results obtained were discussed