potential role of some antioxidants from carotenoids and vitamins on biological and biochemical parameters of hyperlipidemic hamsters

ABSTRACT

This study was conducted to elucidate the effect of some antioxidants [carotenoids lycopene and beta-carotene and vitamins E and C] supplementation on some biological and biochemical parameters of male adult hyperlipidemic hamsters. Lipid profile, lipid peroxidation as MDA, blood and liver GSH, antioxidant enzymes [GPx and GR] and liver function enzymes [ALT and AST] were determined. Hyperlipidemic diet resulted in significant elevation in serum TC, LDL-C, TG, liver MDA and liver function enzymes ALT and AST, with concomitant reduction in serum HDL-C, blood GSH and liver GPx and GR enzymes activity. Supplementation by the Lycopene and vitamin C caused significant reduction in serum TC, LDL-C and TG with significant elevation in serum HDL-C. beta-carotene induced significant reduction only on TC and LDL-c vitamin E showed no obvious effect on lipid profile with highly suppressive effect on lipid peroxidation all individual antioxidants resulted in significant elevation in blood GSH, liver GPx and GR enzymes with concomitant significant reduction in liver MDA and serum ALT and AST