Tanta Medical Journal. 1986; 14 (1): 1103-17
in English
| IMEMR
| ID: emr-8230
ABSTRACT
We investigated the inhibitory effect of verapamil, a calcium channel blocker, against histamine induced contraction [HIC] on the isolated guinea pig tracheal smooth muscle and compared it with aminophylline. Results showed that verapamil [1.1 and 2.2 X 10[-4]M] significantly inhibited HIC when incubated with the tissue before histamine challenge. Aminophylline was less effective when incubated with the tissue in equimolecular concentrations. In higher concentrations however, aminophylline [3.6 X 10[-4]M] significantly prevented HIC. As regards to the reversal of HIC, aminophylline was found to be more potent than verapamil
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Comparative Study
/
Aminophylline
/
Animals, Laboratory
Language:
English
Journal:
Tanta Med. J.
Year:
1986
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