[Association of apolipoprotein E gene polymorphism and obesity in an Iranian population: Tehran Lipid and Glucose study]

ABSTRACT

The Apo E is one of the genes, which play a role in the regulation of lipid metabolism, especially in obesity. In other studies a common Apo E polymorphism has been shown to be associated with obesity, and in the present study our aim is to determine this association in an Iranian population. Subjects were randomly selected from the Tehran Lipid and Glucose Study and classified into 3 in three groups according to their body mass index BMI<25, 25.BMI<30, BMI.30 and finally 429[150 in men and 179 in women]. We measured FBS, HDL-C, triglyceride, cholesterol levels and blood pressure for all individuals. A segment of the mentioned gene with PCR was amplified and the polymorphism with RFLP [HhaI] revealed. The allele frequency of Apo E polymorphism was in the Hardy Weinberg equilibrium and the allele frequency was e2 [0.065], e3 [0.851] and e4 [0.083]; there was no relation between BMI and the frequency of this allele. These results show that there is no relation between Apo E polymorphism and BMI in this study