Histological and histochemical evaluation of the effect of povidone iodine versus sodium hypochlorite on the rat connective tissue

ABSTRACT

Betadine was used in different concentrations ranging from 1% to 10% to study its histological and histochemicol effect on the connective tissue of the adult rat skin. Also a comparison was performed between the effect of betadine and 5% sodium hypochlorite on the some tissue. The lower concentrations of betadine up to 4% gave no injurious action, while 6% betadine was of a relatively lesser tissues reaction than 5% sodium hypochlorite. However, the tissue reaction resulted from 8% betadine was approximately similar to that reported with 5% sodium hypochlorite, Severe tissue reaction was demonstrated with 8% and 10% betadine, which makes the use of this high concentration in root canal disinfection contraindicated