[Prevalence and Antimicrobial susceptibility of Haemophilus influenza among healthy children in Mashhad]

ABSTRACT

Nasopharyngeal colonization of Haemophilus influenza in young children may be important so in this study the nasopharyngeal carriage and antimicrobial susceptibility of Haemophilus influenza among children was surveyed in Mashhad. The study included 1161 healthy children less than 6 years of age. Nasopharyngeal swabs from these patients were cultured, and Haemophilus influenza were isolated. Antibiotic susceptibility of the strains was determined using disk diffusion. The carriage rate of Haemophilus influenza was 10.76% [125/1161]. High antibiotic resistance was observed against commonly administered antibiotics like Penicillin [82.4%], ampicillin [70.4%], Amoxicillin [79.2%] and trimethoprim sulfamethoxazole [71.2%]. It was found that 68.8% and 42.4% of isolates were susceptible against erythromycin and cefexim, respectively. H. influenza isolates from healthy Children in Mashhad had high resistance rates against ampicillin, Sulphamethoxazole/ trimethoprim and some other antibiotics. So antibiotic susceptibility investigations are important for choice of therapy in every acute respiratory tract infection. And further monitoring of antibiotic resistance among nasopharyngeal H. influenza as a surrogate for invasive H. influenza seems an attractive option