prevalence of anti-phospholipid autoantibodies in patients with deep venous thrombosis

ABSTRACT

The aim of the study was to determine the prevalence of antiphospholipid autoantibodies [APLAs] among patients with deep vein thrombosis [DVT]. The APLAs tested were lupus anticoagulant [LA], anticardiolipin [aCL], anti- beta 2 glycoprotein I dependent [a beta 2-GPI], and anti-phosphatidyl serine [aPS]. This study was carried out on 50 patients suffering from DVT events and 30 healthy individuals as a control during the period between 1st March 2004 and 1st March 2005. The studied cases were under 50 years of age, and had no recognizable risk factors. The activated partial thromboplastin time [APTT] was used for LA estimation and ELISA assay was used to test for IgG and IgM isotypes of tested APLAs. The DVT events with significant APLAs was detected in 20/50 [40%] of patients. A significant titers of LA [P > 0.05], total IgG aCL isotype [P > 0.025], and IgG a beta 2-GPI [P > 0.025] were detected in the studied cases, while the correlation was lacking for IgG aPS. The LA, aCL, and a beta 2- GPI significant titers were found to be predominant in DVT patients. Therefore, a panel testing for APLAs is a prudent to correlate such DVT cases as a clinical event related to antiphospholipid syndrome [APS]