hypoglycemic effects of a hydro-alcoholic extract from Securigera securidaca seeds on induced diabetis in male rats

ABSTRACT

Diabetes mellitus is a metabolic disorder of carbohydrates, lipids and proteins caused by deficiency or lack of insulin. The side effects of chemical drugs have increased the requirement to use of medical plants with fewer complications than that of the chemical drugs. Securigera securidaca is one of the medical plants traditionally used. This medicine has antiepileptic, diuretic, hypotensive and hypoglycemic effects. This study was aimed to evaluate the hypoglycemic effect of hydro-alcoholic extract of S. securidaca seeds on streptozocine induced diabetic rats. In this experimental study, a total of seventy Wistar albino male rats were randomly divided into seven groups. Diabetes was induced via intravenous injection of streptozocine [45mg/kg]. Then, the extract of Securigera securidaca seed was administrated orally in dosage of 500, 1000 and 2000 mg/kg in the mice. The blood glucose was measured before and one, two and three weeks after the administration of the extract. Using statistical methods, [Student t test, paired t test and ANOVA], the data were analyzed. Compared with the control group, Streptozocine significantly increased the blood glucose of the test group [p<0.001]. Doses of 500 and 1000 mg/kg of S. securidaca extract had no significant effect on blood glucose after two weeks. However, dose of 2000 mg/kg significantly decreased the blood glucose [p<0.001]. The extract had no significant effect on normal blood glucose in the rats. The findings showed that the extract of S. securidaca seed decreased the blood glucose in streptozocine induced diabetic rats dose-dependently. Therefore, it may be useful in diabetic patients