Bilharziasis and bladder cancer: a time trend analysis of 9843 patients
Journal of the Egyptian National Cancer Institute. 2007; 19 (2): 158-162
in English
| IMEMR
| ID: emr-83649
ABSTRACT
To explore any changes in bladder carcinoma during 37 years period, in regard to its frequency, bilharzia association, histological profile and demographic data. This is a retrospective study on 9843 patients treated at the National Cancer Institute [NCI], Cairo University, during the years 1970-2007. Three groups were selected series [A] included 3212 patients during 1970-1974, series [B] 3988 patients during 1985-1989 and series [C] 2643 patients during 2003-2007. For statistical analysis, data of series [A], [B] and [C] were compared to determine the significance of difference [p value 0.005]. A significant decline of the relative frequency of bladder cancer was observed from 27.63% in the old series to 11.7% in the recent series. Bilharzia association dropped from 82.4% to 55.3%. There was a significant rise of transitional cell carcinomas from 16.0% to 65.8%, becoming at present the most common tumor type, with a significant decrease in squamous cell carcinomas from 75.9% to 28.4%. There was an increase in the median age of patients from 47.4 years to 60.5 years and a decrease of male female [M/F] ratio from 5.4 to 3.3. The decline in the relative frequency of bladder cancer is associated with a decline in bilharzia egg positivity in the specimen and is probably related to better control of bilharziasis in the rural population in Egypt. This was accompanied by a change in the histological profile of tumors, with significant predominance of transitional cell carcinoma and an increase in the age of patients, a pattern rather similar to that in western reports
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Schistosomiasis
/
Biopsy
/
Urinary Bladder Neoplasms
/
Mass Screening
Type of study:
Screening study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Egypt. Natl. Cancer Inst.
Year:
2007
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