Harmful effect of some insecticides on vital parameters of albino rats

ABSTRACT

The present study aims at comparing the in vivo effect among B. thuringiensis [bioinsecticide], chlorpyrifos [organophosphorus insecticide] and flufenoxuron [insect growth regulator] on the biochemical parameters, toxicity some reproductive parameters and histopathological changes in tissue specimens of different organs of albino rats. In flufenoxuron and chlorpyrifos administrated rats body weight and kidney weight significantly decreased as compared with the corresponding weights of the control groups. Also, significant reduction occurred in total protein and serum cholinesterase activity after oral administration of chlorpyrifos and flufenoxuron. Values of total lipids, triglycerides and cholesterol significantly increased throughout the experiment and hyperlipidemia, hypercholesolemia and hyperuremia were noticed in chlorpyrifos and flufenoxuron administrated rats. Also, the mean values of serum transaminases [ALT and AST] and alkaline phosphate [ALP] activities were increased. Prolonged administration of chlorpyrifos caused no effect on hemoglobin concentration, however, it significantly decreased leukocyte count, erythrocyte count, hematocrite values, platelet count and blood indices. On the other hand, flufenoxuron exerted significant decreases in all hematological parameters as compared with the control group. Likewise, chlorpyrifos and flufenoxuron administration significantly decreased testis weight, concentration of sperm cells, percentage of live sperms but on the other hand, caused increase in percentage of abnormal sperms. The orally administration of flufenoxuron and chlorpyrifos led to histopathological changes in liver, kidneys and testis of the treated rats. On the other hand, bio-insecticides [Bacillus thuringiensis] did not show such hazardous effects on the orally administrated rats and consequently it would be safe to people and can be used on all food crops