Lipid metabolism and atherogenic index in turners syndrome

ABSTRACT

Turner's syndrome is the most common sex chromosome abnormality in females. Women with Turner's syndrome have short stature, hypergcnadotrophic hypogonadism and have an increased incidence of coronary heart disease. So, the aim of this work is to study growth parameters, serum FSH, LH, serum lipids and atherogenic index in girls with Turner's syndrome and highlight the correlation between different studied parameters. This work comprise 14 patients with Turner's syndrome [mean age +/- SD 11.93 +/- 3.79 years] and 14 healthy age matched Egyptian females as a control group. Thorough anthropometric measurements were done for patients and control and are expressed as standard deviation score utilizing Egyptian growth table for height and international tables for ideal weight for height. Morning blood sample after overnight fast was used for estimation of serum FSH and LH, serum lipids and atherogenic index. significant decrease in height with significant increase in weight% to ideal weight for height in Turner patients compared to controls with significant higher mean serum FSH, LH, cholesterol, LDL, TG and atherogenic index. Correlation studies showed that height SD score had significant negative correlation with weight% to ideal weight for height, serum LH, FSH and lipid profile. Meanwhile measures of weight% to ideal weight for height showed positive correlation with serum FSH, lipogram with no significant correlation with HDL and atherogenic index. Turner's syndrome is associated with hyperlipidemia and significant increased atherogenic index which explain the liability for coronary heart disease. The degree of lipid disorder is negatively correlated and height SD score