Investigation of circulating anti-coxsackie B, anti- polio and anti-adeno IgG in newly diagnosed T1DM children
Journal of the Faculty of Medicine-Baghdad. 2007; 49 (4): 477-481
in English
| IMEMR
| ID: emr-83864
ABSTRACT
Viruses may be involved in the pathogenesis of Type 1 Diabetes Mellitus [T1DM], either through direct beta-cell infection or as triggers of autoimmunity. To investigate the presence of specific anti- viral IgG antibodies for Coxsackie virus type B [CVB5], Poliovirus, and Adenovirus which proposed to be involved in the etiology of T1DM. A total of 60 Iraqi T1DM children were included in the present study. They were new onset of the disease [diagnosis was from one week up to five months]. For the purpose of comparisons, 50 apparently healthy control subjects were selected. Serum IgG against Coxsackie virus type B[5], Adenovirus type 3, 4, and 7, and Poliovaccin Trivalent were detected quantitatively with an indirect ELISA. High proportion of anti-CVB5 IgG [20%][p<0.05] and anti- Polio IgG [31.67%] were found in T1DM children compared to controls [8%, 26% respectively], while anti- Adeno IgG were detected in diabetic patients only [6.67%][p<1.0001]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunoglobulin G
/
Adenoviridae
/
Child
/
Enterovirus B, Human
/
Poliovirus
/
Diabetes Mellitus, Type 1
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Fac. Med.-Baghdad
Year:
2007
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