comparative study of kinetic parameters of alprazolam in hepatic and renal insufficient patients

ABSTRACT

To compare the kinetic parameters of Alprazolam in both hepatic and renal insufficient patients. Jinnah Postgradute Medical Institute, Karachi. Blood samples were collected from three groups of the patients after giving tablet Alprazolam [0.25 mg B.D] for 21 days. These samples were then analyzed for kinetic parameters i.e. Plasma half life, clearance, plasma concentration and volume of distribution. The parameters included plasma concentration of Alprazolam, clearance [cl], serum alkaline phosphate, serum bilirubin and serum glutamate pyruvate transaminase. Patients were divided into three groups i.e. 1] control, 2] suffering from renal insufficiency, 3] suffering from hepatic insufficiency. On day seven and day twenty one, in the same group [both renal], plasma conc. and t 1/2 increased while Vd and cl decreased. On the other hand in the same group [both hepatic], on day 7 and 21, plasma conc. and t 1/2 increased while Vd and cI decreased. When comparative study done on day 7 and 21 in opposite groups [renal vs hepatic], plasma conc., Vd and t 1/2 increased while cI decreased. In hepatic insufficiency, the doses of Alprazolam [benzodiazepines] should be reduced but in renal insufficiency doses should be reduced in only severe forms of renal dysfunction