Hormonal profile as a prognostic index for patients with 1[st] trimesteric threatened abortion

ABSTRACT

Evidence in the literature is unclear to the exact predictive value of biochemical markers in determining the persistence of threatened abortions. Twenty pregnant women in the 1[st] trimesters, with demonstrable fetal heart pulsations that complained of symptoms, and showed signs of threatened abortion, were included in this prospective, controlled, clinical study. This cohort was divided according to whether or not the pregnancy continued into two groups Group A1 [N=15] that included patients that had an ongoing pregnancy and Group A2 [N=5] that included patients that had an ineirtabl abortion. A control group of twenty randomly chosen healthy women was used as a control group [Group B]. On the day of inclusion, venous blood samples were taken in order to estimate serum CA-125, hCG, progesterone and estradiol levels, Participants were followed up clinically till the gestational age of 14 weeks to distinguish those who had an ongoing pregnancy compared to those who eventually aborted. Of the twenty patients with threatened abortion fifteen aborted and five continued to fourteen weeks gestation. CA-125 levels were higher, and BHCG, progesterone, and E2 levels were lower, in Group A1 when compared to Group A2 and Group B. Maternal serum CA-125, BHCG, progesterone and estrogen may be of value in predicting patients that will gain from expectant management of threatened abortion