Antitumor and antibacterial activity of ethylacetate extract of ludwigia hyssopifolia linn and its active principle piperine

ABSTRACT

An alkaloid constituent 1-[5-[1,3-benzodioxol-5-yl]-1-oxo-2,4-pentadienyl]piperidine, trivial name piperine was isolated from Ludwigia hyssopifolia Linn. [Family-Onagraceae]. The ethylacetate extract of the plant and the isolated compound piperine were studied for antitumor and in vitro antibacterial activity. Ethylacetate extract showed 73.05 and 84.14% inhibition of Agrobacterium tumefaciens-induced crown gall tumor formation in potato disc. Piperine exhibited antitumor activity with IC50 value of 13.50 Gram-negative bacteria