Patient compliance with drug therapy for postmenopausal osteoporosis
PJS-Pakistan Journal of Surgery. 2007; 23 (4): 259-264
in English
| IMEMR
| ID: emr-84958
ABSTRACT
To determine compliance and factors affecting compliance to antiresorptive drugs in osteoporosis, and to compare compliant and non compliant groups in a tertiary care setting. Cross sectional study from May 2004 to April 2007. Hamdard University Hospital, Karachi. A total of 800 patients with postmenopausal osteoporosis were included in the study. The demographic and reproductive characteristics of all the patients were recorded Type of anti-resorptive drugs prescribed, degree of compliance, time and reasons for discontinuation were studied and analyzed. Results:
The mean age of the patients was 64 [ +/- 9] years and their mean duration of follow-up 18 [ +/- 5] months. The prevalence of risk factors for osteoporosis were evenly distributed among treatment groups; 73% patients had a co-morbidity besides osteoporosis while 27% were osteoporotic alone. One or more previous vertebral fractures due to osteoporosis was reported by 14.5% of patients, whereas 35.5% had at least one non-vertebral fracture in their medical history. Out of the total patients 21.5% discontinued the prescribed drug before attending the bone mass re-evaluations, more than half of these within first six months of starting the drugs. The medication that was most frequently discontinued within one year was calcium and vitamin-D [33.7%, p < 0.01] while the least discontinued medication was Alendronate [5.9%, p < 0.01] which is taken once a week. In this study the most important determinant of compliance was the type of drug prescribed and its dose frequency, with a definite preference for Alendronate once a week. Treatment compliance was particularly poor for calcium and vitamin-D regimen, thereby emphasizing the need to find new ways of administering supplements, particularly for vitamin-D
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Vitamin D
/
Prevalence
/
Cross-Sectional Studies
/
Risk Factors
/
Patient Compliance
Type of study:
Prevalence study
Limits:
Female
/
Humans
Language:
English
Journal:
Pak. J. Surg.
Year:
2007
Similar
MEDLINE
...
LILACS
LIS