Evaluation of independent prognostic importance of hyperuricemia in hospital death after acute myocardial infarction

ABSTRACT

To evaluate the role of hyperuricemia [serum uric acid level greater than 7 mg/dl] as an independent short term [in hospital] prognostic factor after acute myocardial infarction [AMI]. Included in the study were 2218 patients who were hospitalized with well established AMI from June 1996 through to December 2002 in the Coronary Care Unit of Ekbatan General Hospital, Hamedan University of Medical Sciences, Iran. All patients with exclusive criteria, were omitted from study. Furthermore, frequency of hyperuricemia in patients [N=59] who expired after AMI was compared with patients [N=104] whom were discharged from the hospital after AMI. Frequency of hyperuricemia was measured according to the extension of myocardial necrosis [as the most important prognostic risk factor] based on serum creatine phosphokinase level greater or less than 2000 IU, which was 13.3% and 20.7% in the case group, and 9.5% and 9.7% in the controls, respectively. These findings indicate that hyperuricemia is not an independent prognostic risk factor in hospital death after AMI