Cerebrospinal fluid involvement in a case of visceral leishmaniasis associated with hemophagocytic lymphohistiocytosis
SQUMJ-Sultan Qaboos University Medical Journal. 2007; 7 (3): 253-256
in English
| IMEMR
| ID: emr-85304
ABSTRACT
Hemophagocytic Lymphohistiocytosis [HLH] implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal fluid changes like mild to moderate pleocytosis [most of the cells are lymphocytes and macrophages] and sometimes hemophagocytosis are seen in primary HLH but are not reported in secondary HLH. Here we report a case of a previously healthy 10 months old male infant who was diagnosed as familial HLH with evidence of CSF hemophagocytosis. He was started on the HLH 2004 treatment protocol with no improvement. A second bone marrow aspiration revealed leshmania donovani antibodies and he was started on anti-leishmania treatment with dramatic response.To the best of our knowledge, this is the first case of secondary HLH with evidence of hemophagocytosis in cerebrospinal fluid
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Leishmania donovani
/
Cerebrospinal Fluid
/
Leishmaniasis, Visceral
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Sultan Qaboos Univ. Med. J.
Year:
2007
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