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Results of hematopoietic cell transplantation in pediatric leukemia
Acta Medica Iranica. 2008; 46 (2): 109-114
in English | IMEMR | ID: emr-85582
ABSTRACT
Hematopoietic cell transplantation [HCT] is an accepted treatment for acute myeloid leukemia [AML] in first remission, the treatment of choice for chronic myeloid leukemia [CML] and high risk groups of ALL who relapse with conventional chemotherapy. We assessed results of HCT for pediatric leukemia in our center. A total of 92 children, 63 with diagnose of AML, 23 with ALL and 6 with CML received allogeneic transplantation from HLA full matched siblings [57.6%] and autologous transplantation [42.4%]. Source of hematopoietic cells were peripheral blood 83.7%, bone marrow 15.2% and cord blood 1.6%. The median transplanted nucleated cells were 6.4 +/- 4.7 X 10[8] /Kg [body weight of patients] and mononuclear cells were 5.5 +/- 2.9 X 10[8]/Kg. The most common conditioning regimens were cyclophosphamide + busulfan. Prophylaxis regimen for GVHD was cyclosporin +/- methotrexate. GVHD occurred in 50 [54.3%] patients. Eighty five of children had engraftment, 26 [28.6%] relapsed and 57 [62%] are alive. The most common cause of death was relapse [68.6%]. Five years overall survival of patients with AML and ALL were 49% and 44% respectively and disease free survival of them were 52% and 49%. One year overall survival and disease free survival of CML was 57%. Overall survival increased with increasing age of patients at transplantation time [P = 0.06]. Longer survival significantly related to earlier WBC and platelet recovery [P < 0.0001 and P = 0.006 respectively]. Considering acceptable overall and disease free survival of patients after HCT, we concluded that is a good modality in treatment of leukemia of children
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Index: IMEMR (Eastern Mediterranean) Main subject: Transplantation, Autologous / Transplantation, Homologous / Leukemia / Child / Survival Rate / Treatment Outcome / Cyclophosphamide / Cord Blood Stem Cell Transplantation / Peripheral Blood Stem Cell Transplantation / Graft vs Host Disease Limits: Female / Humans / Male Language: English Journal: Acta Med. Iran. Year: 2008

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Index: IMEMR (Eastern Mediterranean) Main subject: Transplantation, Autologous / Transplantation, Homologous / Leukemia / Child / Survival Rate / Treatment Outcome / Cyclophosphamide / Cord Blood Stem Cell Transplantation / Peripheral Blood Stem Cell Transplantation / Graft vs Host Disease Limits: Female / Humans / Male Language: English Journal: Acta Med. Iran. Year: 2008