role of adverse lifestyle changes in the causation of coronary artery disease

ABSTRACT

Adverse lifestyle changes like rapid change in dietary habits coupled with decreased physical activity and increasing rates of alcohol and tobacco consumption can increase coronary artery disease [CAD] risk factors and its mortality even higher than the rates predicted. To evaluate the role of adverse lifestyle changes factors in the causation of CAD, a hospital based case-control study was conducted in an urban area of East Delhi from April 2002 to December 2003. A total of 500 subjects with age group 30-75 [250 cases and 250 controls], were included in this study. To obtain more validate comparisons, 250 controls also was selected from community of East Delhi. The tool of enquiry was a pre-tested and pre-coded questionnaire. A confidence level of 95% and study power of 80% were considered for the interpretation of possible significant findings. Sexwise stratified analysis was separately done for male and female subjects using Multiple Logistic Regression. Comparison of male cases with their counterparts in both control groups indicated that milk consumption, using saturated oils for cooking medium, and tobacco consumption could account for as CAD independent predictors [P < 0.001]. The comparison of female cases with their counterparts in both control groups also showed that majority of those significantly were nuts consumer. Male cases compared to males in hospital group and female cases compared with females in community control group significantly were nuts consumer and used saturated oils in their cookings respectively. Our study showed that dietary factors such as consumption of milk, nuts, saturated oils and smoking, as misbehavior factor, could play an important role in the causation of CAD in urban area of East Delhi, India