Studying the effect of L-ascorbic acid on oral hypoglycemic drug [gliclazid] in treatment of diabetic albino rats

ABSTRACT

In this work, thirty adult male albino rats were used to study the effect of L - ascorbic acid on oral hypoglycemic drug [gliclazid] in treatment of diabetic rats. Rats were divided into three equal groups, I, II, III. Rats subjected to induction of diabetes by alloxan 100 mg /kg body weight. Rats showing fasting blood glucose level above 150 mg/dl were selected for the study. Group I received gliclazid 7 mg/Kg body weight Group II received gliclazid 7 mg/kg + L .ascorbic acid [L .A .A] 40 mg/Kg body weight. Group III received gliclazid 7 mg/kg + L .A .A 60 mg/kg body weight. Blood glucose level determined at different time interval after administration of drugs. The study showed that L.A.A produced hypoglycemic effect in a dose dependent manner in diabetic rats. Also, L.A.A/gliclazid produced early onset of action and maintained for long period compared to gliclazid treatment only