[Comparative efficacy of 10% sodium sulfacetamide lotion and 1% clotrimazole lotion in treatment of tinea versicolor]

ABSTRACT

Tinea versicolor is a common superficial fungal infection caused by normal skin flora and many topical and oral anti-fungal medications have been used for its treatment. The aim of this study was to compare the therapeutic effects of 10% sodium Sulfacetamide lotion with 1% Clotrimazole lotion in treatment of tinea versicolor. In this single-blind clinical trial 67 patients were divided into two groups using block randomization method. The first group consisted of 33 patients who were treated with 1% clotrimazole lotion. The second group included 34 patients who received 10% sodium sulfacetamide lotion. After 2 weeks of treatment, both groups were evaluated for clinical and paraclinical responses. The collected data were recorded in a data sheet and analyzed by X[2] and independent T tests, using SPSS software. After 2 weeks of treatment, clinical and paraclinical responses were seen in 22 patients [66.7%] and 28 patients [84.8%] in the first group [clotrimazole lotion] and in 7 [20.6%] and 8 [23.5%] patients of the second group [sodium sulfacetamide lotion], respectively. Statistical analysis showed that the differences are significant. The therapeutic effect of 10% sodium sulfacetamide lotion is much less than that of 1% clotrimazole lotion in treatment of tinea versicolor