Corpora amylacea in human cadaveric brain age related differences

ABSTRACT

The present study was designed to investigate the age related deposits of corpora amylacea [CA] in the human cadaveric brain. It is an observational study which was conducted in the Department of Anatomy, University of Health Sciences, Lahore. The duration of the study was two years. Sixty brain specimens [age 19-72 years] from cadavers were collected from the mortuary of the King Edward Medical University, Lahore and were divided into two groups, A and B comprising less than and more than sixty years of age respectively. CA were observed in memory related areas of the brain specially in frontal lobe and hippocampus. The presence and location of CA in two groups were compared with each other. Statistical analysis was carried out, using Chi Square test. The results showed significant increase in the presence of CA in frontal lobe and hippocampus with advancing age and the difference was statistically significance in these locations [p < 0.00005 and p < 0.0001] respectively. The presence and number of CA is age related; it is contended that it interferes with the function of neurons and presumably affects the memory