Effect of low or normal protein diets and green tea extract on rats suffering from chronic renal failure

ABSTRACT

The present work was conducted to study the influence of low or normal protein diet content and different levels of green tea extract on rats suffering from chronic renal failure [CRF]. Sixty three male rats [200 - 210g] were established in this study. The rats are divided into two main groups. Group 1 [n=7 rats] used as a negative control group fed on basal diet [B.D]. The other group [n= 56 rats] fed on basal diet containing 2% W/W arginine for two weeks to induce chronic renal failure [CRF], then this group was divided into eight subgroups [n=7 rats]. Which were fed on low or normal protein diet. Throughout the experimental period [4 weeks], subgroups 3, 4 and 5 also 6, 7 and 8 were given 2 ml, green tea extract from 10g, 15g and 20g green tea, twice daily, respectively. Results indicated that, kidneys weight / body weight% was decreased significantly in all tested groups, as compared to the positive control groups. The mean values of serum uric acid, urea nitrogen, creatinine, sodium, potassium, and phosphorus as well as liver enzymes [AST and ALT] inhibited significantly in all CRF groups which were fed on low or normal protein diet and treated with the different concentration from green tea extract, while serum calcium increased, as compared to CRF groups [positive control groups]. Groups of rats fed on low protein diet and treated with tea extract from 15 and 20g green tea realized the best results. In conclusion, low protein diets with 15 or 20g green tea extract realized the best modulating effects in chronic renal failure